• Vaccine Name: Salmonella Typhimurium ruvB mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Vaccine Ontology ID: VO_0002909
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• ruvB gene engineering:
  • Type: Gene mutation
  • Description: This ruvB mutant is from Salmonella Typhimurium (Choi et al., 2010).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: A ruvB mutant is attenuated in mice (Choi et al., 2010).
• Efficacy: A ruvB mutant provides protection in mice from challenge with wild type Salmonella Typhimurium (Choi et al., 2010).
• Host Ifng (Interferon gamma) response
  • Description: The vaccine induced significant production of IFN-γ on days 18 and 22 after vaccination while the control mice (non vaccinated) showed no change in the level of IFN-γ (Choi et al., 2010).
  • Detailed Gene Information: Click Here.
• Host IgG response
  • Description: Total IgG levels were significantly increased in vaccinated mice compared to the non-vaccinated group at both day 18 and day 22 (Choi et al., 2010).
  • Detailed Gene Information: Click Here.