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Vaccine Detail
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Salmonella Typhimurium rpoS mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella Typhimurium rpoS mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002908
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- rpoS
gene engineering:
- Type: Gene mutation
- Description: This rpoS mutant is from Salmonella Typhimurium (Coynault et al., 1996).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: An rpoS mutant is attenuated in mice (Coynault et al., 1996).
- Efficacy: An rpoS mutant protects mice from challenge with wild type Salmonella typhimurium after a single dose (Coynault et al., 1996).
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| References |
Coynault et al., 1996: Coynault C, Robbe-Saule V, Norel F. Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon. Molecular microbiology. 1996; 22(1); 149-160. [PubMed: 8899717].
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