• Vaccine Name: Salmonella Gallinarum relA/spoT mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Chickens
• relA gene engineering:
  • Type: Gene mutation
  • Description: This relA/spoT mutant is from Salmonella Gallinarum (Park et al., 2010).
  • Detailed Gene Information: Click Here.
• spoT gene engineering:
  • Type: Gene mutation
  • Description: This relA/spoT mutant is from Salmonella Gallinarum (Park et al., 2010).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Persistence: A relA/spoT mutant is attenuated in chickens (Park et al., 2010).
• Efficacy: A relA/spoT mutant induces significant protection in chickens from challenge with wild type Salmonella Gallinarum (Park et al., 2010).
• Host IgA Fc receptor response
  • Description: Serum IgG and IgA peaked at 3-4 wpi and was a significant antibody response against Salmonella vs. unimmunized chickens (Park et al., 2010).
  • Detailed Gene Information: Click Here.
• Host IgG Fc fragment response
  • Description: Serum IgG and IgA peaked at 3-4 wpi and was a significant antibody response against Salmonella vs. unimmunized chickens (Park et al., 2010).
  • Detailed Gene Information: Click Here.
• Host IgM Fc receptor response
  • Description: The serum IgM levels against Salmonella in all chickens immunized with the mutant strains increased up to 3 weeks post infection (wpi), and subsequently decreased. The titers were significant vs. unimmunized chickens (Park et al., 2010).
  • Detailed Gene Information: Click Here.