• Vaccine Name: Salmonella Typhi phoP mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Vaccine Ontology ID: VO_0002903
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• PhoP gene engineering:
  • Type: Gene mutation
  • Description: This phoP mutant is from Salmonella Typhi (Lee et al., 2007).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: A phoP mutant is attenuated in mice (Lee et al., 2007).
• Efficacy: A phoP mutant provides significant protection in mice from challenge with wild type S. Typhi (Lee et al., 2007).
• Host IgG response
  • Description: The serum titer of IgG was more than 1000-fold higher in mice immunized with a phoP mutant than in control mice. The mutant induced high titers of serum IgG against lipopolysaccharide of S. typhi at 8 weeks in the immunization schedule (Lee et al., 2007).
  • Detailed Gene Information: Click Here.
• Host IgG2b response
  • Description: The titers of serum IgG2b increased significantly 8 weeks after inoculation in mice immunized with a phoP mutant as compared to unimmunized control mice (Lee et al., 2007).
  • Detailed Gene Information: Click Here.
• Host Ighv1-9 response
  • Description: Titers of serum IgG2a increased significantly 8 weeks after inoculation in mice immunized with a phoP mutant as compared to unimmunized control mice (Lee et al., 2007).
  • Detailed Gene Information: Click Here.