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Vaccine Detail
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Salmonella Typhimurium ompR mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella Typhimurium ompR mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002902
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- ompR
gene engineering:
- Type: Gene mutation
- Description: This ompR mutant is from Salmonella Typhimurium (Dorman et al., 1989).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Persistence: An ompR mutant is attenuated in mice after oral challenge (Dorman et al., 1989).
- Efficacy: A ompR mutant conferred significant protection in mice from challenge with wild type Salmonella Typhimurium (Dorman et al., 1989).
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| References |
Dorman et al., 1989: Dorman CJ, Chatfield S, Higgins CF, Hayward C, Dougan G. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infection and immunity. 1989; 57(7); 2136-2140. [PubMed: 2543631].
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