• Vaccine Name: Salmonella Typhimurium hfq mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Vaccine Ontology ID: VO_0002892
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• hfq gene engineering:
  • Type: Gene mutation
  • Description: This hfq mutant is from Salmonella Typhimurium (Allam et al., 2011).
  • Detailed Gene Information: Click Here.
• Immunization Route: Oral immunization

Mouse Response

• Persistence: An hfq mutant is attenuated in mice (Allam et al., 2011).
• Efficacy: An hfq mutant efficiently protects mice against subsequent oral challenge with virulent strain of Salmonella Typhimurium (Allam et al., 2011).
• Host Ifng (Interferon gamma) response
  • Description: Vaccinated mice had significantly higher serum IFN-γ and IL-6 than the PBS administered mice. The serum IL-6 and IFN-γ levels of vaccinated mice further increased upon challenge while remaining lower than that of unvaccinated challenged mice. Serum was collected 7 days after vaccination from unchallenged mice or 7 days after challenge from challenged mice (Allam et al., 2011).
  • Detailed Gene Information: Click Here.
• Host IgA response
  • Description: Mucosal IgA and serum IgG levels significantly increased in vaccinated mice compared to naive mice. The antibody titers remained high in case of mice vaccinated and challenged compared with the unvaccinated and challenged mice. The elicited humoral immune response remained 4 weeks after immunization with mutant strain (Allam et al., 2011).
  • Detailed Gene Information: Click Here.
• Host IgG response
  • Description: Mucosal IgA and serum IgG levels significantly increased in vaccinated mice compared to naive mice. The antibody titers remained high in case of mice vaccinated and challenged compared with the unvaccinated and challenged mice. The elicited humoral immune response remained 4 weeks after immunization with mutant strain (Allam et al., 2011).
  • Detailed Gene Information: Click Here.
• Host IL-6 response
  • Description: Vaccinated mice had significantly higher serum IFN-γ and IL-6 than the PBS administered mice. The serum IL-6 and IFN-γ levels of vaccinated mice further increased upon challenge while remaining lower than that of unvaccinated challenged mice. Serum was collected 7 days after vaccination from unchallenged mice or 7 days after challenge from challenged mice (Allam et al., 2011).
  • Detailed Gene Information: Click Here.