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Vaccine Detail

Salmonella Typhi galE mutant vaccine

Vaccine Information

Vaccine Name: Salmonella Typhi galE mutant vaccine
Target Pathogen: Salmonella spp.
Target Disease: Salmonellosis
Vaccine Ontology ID: VO_0002883
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
galE gene engineering:
- Type: Gene mutation
- Description: This galE mutant is from Salmonella Typhi (Germanier and Füer, 1975).
- Detailed Gene Information: Click Here.
Immunization Route: Intraperitoneal injection (i.p.)

Host Response

Mouse Response

Persistence: A galE mutant is attenuated in mice (Germanier and Füer, 1975).
Efficacy: A galE mutant protects mice from lethal challenge with Salmonella Typhi (Germanier and Füer, 1975).

References

Germanier and Füer, 1975: Germanier R, Füer E. Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine. The Journal of infectious diseases. 1975; 131(5); 553-558. [PubMed: 1092768].