|
|
Vaccine Detail
|
Salmonella Gallinarum cpxR/Ion mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella Gallinarum cpxR/Ion mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002877
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- cpxR
gene engineering:
- Type: Gene mutation
- Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
- Detailed Gene Information: Click Here.
- lon
gene engineering:
- Type: Gene mutation
- Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Persistence: A cpxR/Ion mutant is highly attenuated in mice (Matsuda et al., 2010).
- Efficacy: A cpxR/Ion mutant induces significant protection in mice from challenge with wild type S. Gallinarum (Matsuda et al., 2010).
|
| References |
Matsuda et al., 2010: Matsuda K, Chaudhari AA, Kim SW, Lee KM, Lee JH. Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid. Veterinary research. 2010; 41(5); 59. [PubMed: 20487719].
|
|
