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Vaccine Detail

Salmonella Gallinarum cpxR/Ion mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Gallinarum cpxR/Ion mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • cpxR gene engineering:
    • Type: Gene mutation
    • Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
    • Detailed Gene Information: Click Here.
  • lon gene engineering:
    • Type: Gene mutation
    • Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Persistence: A cpxR/Ion mutant is highly attenuated in mice (Matsuda et al., 2010).
  • Efficacy: A cpxR/Ion mutant induces significant protection in mice from challenge with wild type S. Gallinarum (Matsuda et al., 2010).
References
Matsuda et al., 2010: Matsuda K, Chaudhari AA, Kim SW, Lee KM, Lee JH. Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid. Veterinary research. 2010; 41(5); 59. [PubMed: 20487719].