VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Detail

SARS-CoV E gene mutant vaccine

Vaccine Information

Vaccine Name: SARS-CoV E gene mutant vaccine
Target Pathogen: SARS-CoV
Target Disease: Severe Acute Respiratory Syndrome (SARS)
Vaccine Ontology ID: VO_0002993
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Hamster
envelope protein (E) gene of SARS-CoV gene engineering:
- Type: Gene mutation
- Description: This E gene is from SARS coronavirus (Lamirande et al., 2008).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Hamster Response

Host Strain: LVG (SYR) (Lamirande et al., 2008)
Host age: 7 weeks (Lamirande et al., 2008)
Host gender: Male (Lamirande et al., 2008)
Persistence: An E gene mutant is attenuated in hamsters (Lamirande et al., 2008).
Immune Response: Induced neutralizing antibodies. (Lamirande et al., 2008)
Efficacy: An E gene mutant induces significant protection in hamsters from challenge with wild type SARS (Lamirande et al., 2008).

References

Lamirande et al., 2008: Lamirande EW, DeDiego ML, Roberts A, Jackson JP, Alvarez E, Sheahan T, Shieh WJ, Zaki SR, Baric R, Enjuanes L, Subbarao K. A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters. Journal of virology. 2008; 82(15); 7721-7724. [PubMed: 18463152].