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Vaccine Detail
T. gondii mic2 mutant vaccine |
Vaccine Information |
- Vaccine Name: T. gondii mic2 mutant vaccine
- Target Pathogen: Toxoplasma gondii
- Target Disease: Toxoplasmosis
- Vaccine Ontology ID: VO_0003012
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- mic2
gene engineering:
- Immunization Route: Intraperitoneal injection (i.p.)
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Host Response |
Mouse Response
- Persistence: A mic2 mutant is attenuated in mice (Huynh and Carruthers, 2006).
- Efficacy: A mic2 mutant induces protection in mice from challenge with wild type T. gondii (Huynh and Carruthers, 2006).
- Host Ccl2 response
- Description: Levels of serum MCP-1 (Ccl2) were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click Here.
- Host Ifng (Interferon gamma) response
- Description: Levels of serum IFN-gamma were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click Here.
- Host IL-6 response
- Description: Levels of serum IL-6 were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click Here.
- Host Il12b response
- Description: Levels of serum IL-12p40 (IL-12b) were higher than those of uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click Here.
- Host TNF-alpha response
- Description: Levels of serum TNF-alpha were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click Here.
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References |
Huynh and Carruthers, 2006: Huynh MH, Carruthers VB. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS pathogens. 2006; 2(8); e84. [PubMed: 16933991].
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