• Vaccine Name: Yersinia enterocolitica sodA mutant vaccine
• Target Pathogen: Yersinia enterocolitica
• Target Disease: Yersiniosis
• Vaccine Ontology ID: VO_0002938
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• sodA gene engineering:
  • Type: Gene mutation
  • Description: This sodA mutant is from Yersinia enterocolitica (Igwe et al., 1999).
  • Detailed Gene Information: Click Here.
• Immunization Route: Oral immunization

Mouse Response

• Persistence: A sodA mutant is attenuated in mice (Igwe et al., 1999).
• Efficacy: A single dose of a sodA mutant provided protection in mice from challenge with wild type Y. enterocolitica (Igwe et al., 1999).
• Host Ifng (Interferon gamma) response
  • Description: Restimulated T cells from mice immunized with the mutant strains produced significant quantities of IFN-γ by day 8 after oral immunization compared to the control group of nonrestimulated T cells. However, the amounts of IFN-γ produced by T cells from mice immunized with the mutant strains were lower than those of mice immunized with the wild-type Y. enterocolitica strain (Igwe et al., 1999).
  • Detailed Gene Information: Click Here.
• Host IgG response
  • Description: Mice immunized with a sodA mutant elicited high titers of serum IgG antibodies. On day 23, WA-314 sodA elicited a 17-fold-higher titer of Yersinia-specific serum IgG antibody than WA irp1 (an irp1 mutant). Mice immunized with WA-314 sodA elicited a 10-fold-higher titer of serum IgG antibody than those given WA(pYVO8-A-2) (a YadA mutant) 90 days after the immunization. IgG levels from days 7 to 90 post-immunization were significantly greater than control serum obtained pre-immunization (Igwe et al., 1999).
  • Detailed Gene Information: Click Here.