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Vaccine Detail

Yersinia enterocolitica htrA mutant vaccine
Vaccine Information
  • Vaccine Name: Yersinia enterocolitica htrA mutant vaccine
  • Target Pathogen: Yersinia enterocolitica
  • Target Disease: Yersiniosis
  • Vaccine Ontology ID: VO_0002936
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • htrA gene engineering:
    • Type: Gene mutation
    • Description: This htrA mutant is from Yersinia enterocolitica (Li et al., 1996).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Mouse Response

  • Persistence: An htrA mutant is attenuated in mice (Li et al., 1996).
  • Efficacy: An htrA mutant provides partial protection in mice from challenge with wild type Y. enterocolitica (Li et al., 1996).
References
Li et al., 1996: Li SR, Dorrell N, Everest PH, Dougan G, Wren BW. Construction and characterization of a Yersinia enterocolitica O:8 high-temperature requirement (htrA) isogenic mutant. Infection and immunity. 1996; 64(6); 2088-2094. [PubMed: 8675311].