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Vaccine Detail
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Yersinia enterocolitica aroA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Yersinia enterocolitica aroA mutant vaccine
- Target Pathogen: Yersinia enterocolitica
- Target Disease: Yersiniosis
- Vaccine Ontology ID: VO_0002935
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- aroA
gene engineering:
- Type: Gene mutation
- Description: This aroA mutant is from Yersinia enterocolitica (Bowe et al., 1989).
- Detailed Gene Information: Click Here.
- Immunization Route: Oral immunization
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| Host Response |
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Mouse Response
- Persistence: An aroA mutant is highly attenuated in mice (Bowe et al., 1989).
- Efficacy: After 3 doses, an aroA mutant induces significant protection in mice from challenge with wild type Y. enterocolitica (Bowe et al., 1989).
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| References |
Bowe et al., 1989: Bowe F, O'Gaora P, Maskell D, Cafferkey M, Dougan G. Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants. Infection and immunity. 1989; 57(10); 3234-3236. [PubMed: 2777382].
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