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Vaccine Detail
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Yersinia pestis guaBA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Yersinia pestis guaBA mutant vaccine
- Target Pathogen: Yersinia pestis
- Target Disease: Plague
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- guaA
gene engineering:
- Type: Gene mutation
- Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
- Detailed Gene Information: Click Here.
- guaB
gene engineering:
- Type: Gene mutation
- Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Persistence: A guaBA mutant is attenuated in mice (Oyston et al., 2010).
- Efficacy: A guaBA mutant induced significant protection from challenge with wild type Yersinia pestis in mice (Oyston et al., 2010).
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| References |
Oyston et al., 2010: Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS. A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microbial pathogenesis. 2010; 48(5); 191-195. [PubMed: 20096773].
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