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Vaccine Detail

Yersinia pseudotuberculosis phoP mutant vaccine

Vaccine Information

Vaccine Name: Yersinia pseudotuberculosis phoP mutant vaccine
Target Pathogen: Yersinia pseudotuberculosis
Target Disease: Yersiniosis
Vaccine Ontology ID: VO_0002947
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
phoP gene engineering:
- Type: Gene mutation
- Description: This phoP mutant is from Yersinia pseudotuberculosis IP 32953 (Balada-Llasat et al., 2007).
- Detailed Gene Information: Click Here.
Immunization Route: Oral immunization

Host Response

Mouse Response

Persistence: A phoP mutant is attenuated in mice (Balada-Llasat et al., 2007).
Efficacy: A phoP mutant provided protection against oral challenge with wild type Yersinia pseudotuberculosis (Balada-Llasat et al., 2007).

References

Balada-Llasat et al., 2007: Balada-Llasat JM, Panilaitis B, Kaplan D, Mecsas J. Oral inoculation with Type III secretion mutants of Yersinia pseudotuberculosis provides protection from oral, intraperitoneal, or intranasal challenge with virulent Yersinia. Vaccine. 2007; 25(8); 1526-1533. [PubMed: 17194509].