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Vaccine Detail

Yersinia ruckeri aroA mutant vaccine

Vaccine Information

Vaccine Name: Yersinia ruckeri aroA mutant vaccine
Target Pathogen: Yersinia ruckeri
Target Disease: Enteric redmouth disease
Vaccine Ontology ID: VO_0002948
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Rainbow trout
aroA gene engineering:
- Type: Gene mutation
- Description: The aroA gene is mutated in Yersinia ruckeri (Temprano et al., 2005).
- Detailed Gene Information: Click Here.
Immunization Route: Intraperitoneal injection (i.p.)

Host Response

Rainbow trout Response

Persistence: An aroA mutant is attenuated in rainbow trout (Temprano et al., 2005).
Efficacy: An aroA mutant provided significant protection from challenge with wild type Y. ruckeri (Temprano et al., 2005).

References

Temprano et al., 2005: Temprano A, Riaño J, Yugueros J, González P, de Castro L, Villena A, Luengo JM, Naharro G. Potential use of a Yersinia ruckeri O1 auxotrophic aroA mutant as a live attenuated vaccine. Journal of fish diseases. 2005; 28(7); 419-427. [PubMed: 16083447].