• Vaccine Name: P. falciparum MSA-2 subunit vaccine
• Target Pathogen: Plasmodium spp.
• Target Disease: Malaria
• Vaccine Ontology ID: VO_0004269
• Type: Subunit vaccine
• Status: Research
• Antigen: merozoite antigen, MSA-2 (Pye et al., 1997).
• MSP2 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001349
• Immunization Route: Intramuscular injection (i.m.)

Sheep Response

• Vaccination Protocol: Sheep were immunized intramuscularly (i.m.) in the left rear leg, with a second immunization in the right rear leg 4 weeks later. A 100 μg antigen dose was delivered in 1.0 ml. Serum was prepared from bleeds taken prior to the first immunization, 3 or 4 weeks later (i.e. prior to the second dose), and a final bleed 2 weeks after the second immunization (Pye et al., 1997).
• Immune Response: Sheep immunized with MSA-2 and SAF-1 had higher antibody response than sheep immunized with MSA-2 and alhydrogel (Pye et al., 1997).