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Vaccine Detail
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Hepatitis B surface antigen (HBsAg) with JVRS-1000 |
| Vaccine Information |
- Vaccine Name: Hepatitis B surface antigen (HBsAg) with JVRS-1000
- Target Pathogen: Hepatitis B virus
- Target Disease: Hepatitis B
- Vaccine Ontology ID: VO_0004260
- Type: Subunit vaccine
- Status: Research
- Antigen: Hepatitis B surface antigen (HBsAg) (Morrey et al., 2011).
- Adjuvant:
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Host Strain: C57BL/6
- Vaccination Protocol: HBV transgenic mice were vaccinated with HBsAg (i.m., 5 μg), or HBsAg plus JVRS-100 (i.v., 10 μg) in female C57BL/6 mice (>6 weeks). Animals were treated on days 1, 22, and 43 (Morrey et al., 2011).
- Immune Response: JVRS-100 combined with hepatitis B surface antigen (HBsAg) broke tolerance by stimulating significant B and T cell responses. The combination of HBsAg + JVRS-100 elicited a T cell response as indicated by increased levels of IFN-γ in splenocyte cell-culture supernatant (Morrey et al., 2011).
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| References |
Morrey et al., 2011: Morrey JD, Motter NE, Chang S, Fairman J. Breaking B and T cell tolerance using cationic lipid-DNA complexes (CLDC) as a vaccine adjuvant with hepatitis B virus (HBV) surface antigen in transgenic mice expressing HBV. Antiviral research. 2011; 90(3); 227-230. [PubMed: 21545812].
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