• Vaccine Name: recombinant S gene Hepatitis B Vaccine with rIFN-gamma
• Target Pathogen: Hepatitis B virus
• Target Disease: Hepatitis B
• Vaccine Ontology ID: VO_0004251
• Type: Subunit vaccine
• Status: Research
• Antigen: Recombinant S gene of hepatitis B (Quiroga et al., 1990).
• Adjuvant: recombinant hIFN-gamma/Interferon-g vaccine adjuvant
  • Adjuvant name: recombinant hIFN-gamma/Interferon-g vaccine adjuvant
  • VO adjuvant ID: VO_0001296
• Immunization Route: Intramuscular injection (i.m.)

Human Response

• Vaccination Protocol: 81 adult white hemodialysis patients (46 men, 35 women aged 19-65 yrs) with no serological evidence of immunity to hepatitis B were used in the study. Patients were randomly allocated to one of two groups. Group I comprised 41 patients who recieved 40μg of recombinant (S gene) hepatitis B vaccine by i.m. injection and 0,1, and 6 months. Group II comprised 40 patients who received 40 μg of recombinant (S gene) hepatitis B vaccine given intramuscularly with 2 million units (MU) of rIFN-gamma/m^2 body surface given subcutaneously at 0,1, and 6 months (Quiroga et al., 1990).
• Immune Response: The titers of anti-HBs achieved among patients who received vaccine and rIFN-gamma were higher than among those receiving the vaccine alone (Quiroga et al., 1990).