• Vaccine Name: attenuated Listeria expressing cancer antigen vaccine
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004250
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: mouse
• E7 gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0000068
• Preparation: Attenuated LM were genetically modified to express HPV16 E7 protein (Jia et al., 2017).
• Immunization Route: Intravenous injection (i.v.)
• Description: This vaccine has been used in trials involving cervical cancer. (Jia et al., 2017)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Female BALB/c mice were implanted i.v. with 2 × 10^5 CT26 cells on day 0. Four days later, mice were randomized and vaccinated i.v. with the indicated Listeria strains or Hanks' balanced salt solution (HBSS) as negative control (Brockstedt et al., 2004).
• Challenge Protocol: Female BALB/c mice were implanted i.v. with 2 × 10^5 CT26 cells on day 0 (Brockstedt et al., 2004).
• Efficacy: Therapeutic vaccination of CT26 tumor-bearing mice with ΔactA/ΔinlB-AH1-A5, but not with the ΔactA control strain, resulted in a significant prolongation of life with 40% long-term survivors (P < 0.0001) (Brockstedt et al., 2004).