• Vaccine Name: Mutagrip Vaccine with P40 Adjuvant
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004249
• Type: Inactivated or "killed" vaccine
• Status: Research
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000146
• Immunization Route: subcutaneous injection

Mouse Response

• Host Strain: Swiss
• Vaccination Protocol: Female swiss mice were vaccinated with the "Mutagrip" influenza vaccine, consisting of a mix of strains: A/Mississipi/1/85, A/Chili/1/83, B/Ann Arbor/1/86. One tenth of a human vaccinal dose was injected subcutaneously into the inguinal fold of each mouse 10 days before challenge. The immunomodulator p40 was administered in combination with the vaccine (Fattal-German et al., 1988).
• Challenge Protocol: Mice were challenged with a mouse adapted strain of influenza (H1N1) and was given to mice via aerosol (Fattal-German et al., 1988).
• Efficacy: When given the vaccine plus p40, 50% of mice survived virus challenge (Fattal-German et al., 1988).