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Vaccine Detail
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Recombinant Colorectal cancer antigen GA733 Vaccine |
| Vaccine Information |
- Vaccine Name: Recombinant Colorectal cancer antigen GA733 Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004245
- Type: Subunit vaccine
- Status: Research
- Antigen: Recombinant GA733-2 Ag (Basak et al., 2000).
- EPCAM
gene engineering:
- Type: Recombinant protein preparation
- Description: (Basak et al., 2000)
- Detailed Gene Information: Click Here.
- Adjuvant: Theramide vaccine adjuvant
- Immunization Route: subcutaneous injection
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: BALB/c mice were immunized s.c. with BV GA733-2F (full-length) proteins (25 μg) in theramide adjuvant (25 μg), 3× at 3-week intervals (Basak et al., 2000).
- Challenge Protocol: Seventeen days after the last immunization mice were challenged with 2.5 × 10^7 CT26-GA733 tumor cells (Basak et al., 2000).
- Efficacy: 1 out of 7 mice was tumor free after immunization and challenge with tumor cells (Basak et al., 2000).
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| References |
Basak et al., 2000: Basak S, Eck S, Gutzmer R, Smith AJ, Birebent B, Purev E, Staib L, Somasundaram R, Zaloudik J, Li W, Jacob L, Mitchell E, Speicher D, Herlyn D. Colorectal cancer vaccines: antiidiotypic antibody, recombinant protein, and viral vector. Annals of the New York Academy of Sciences. 2000; 910; 237-252. [PubMed: 10911917].
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