• Vaccine Name: HBsAg Liposomal MTP-PE Vaccine
• Target Pathogen: Hepatitis B virus
• Target Disease: Hepatitis B
• Vaccine Ontology ID: VO_0004239
• Type: Subunit vaccine
• Status: Research
• Antigen: HBsAg (Jain et al., 2009).
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001302
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Host Strain: Swiss
• Vaccination Protocol: Alum-adsorbed antigen, liposomes (with or without MTP-PE and with or without MDP-GDP) with HBsAg antigen or liposomes (with or without MTP-PE and with or without MDP-GDP) without HBsAg antigen, in a dose equivalent to 10 μg HBsAg were injected intramuscularly and recombinant pure HBsAg was used as control. The immunomodulator doses given with each injection were 20 μg of MTP-PE and 10 μg of MDP-GDP. Secondary immunization was done after 4 weeks with the same formulations (Jain et al., 2009).
• Immune Response: The incorporation of MTP-PE on the liposomal HBsAg increased the stimulation index (SI) four to five times as compared to plain HBsAg solution, and it also induced significantly higher Th1 cellular immune response with a predominant IFN-γ level (Jain et al., 2009).