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Vaccine Detail

V3 VLPs with Gamma inulin adjuvant
Vaccine Information
  • Vaccine Name: V3 VLPs with Gamma inulin adjuvant
  • Target Pathogen: Human Immunodeficiency Virus
  • Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
  • Vaccine Ontology ID: VO_0004232
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: gp120 V3 loop (Harris et al., 1996).
  • Adjuvant:
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Host Strain: BABL/c
  • Vaccination Protocol: Mice were immunized with 10 μg of V3-VLPs without adjuvant in the muscle of the left leg. At the same time, the mice were immunized in the right leg with the other immunogens (Harris et al., 1996).
  • Immune Response: Mice immunized with V3 VLPs adjuvanted with gamma inulin showed good CTL responses (Harris et al., 1996).
References
Harris et al., 1996: Harris SJ, Woodrow SA, Gearing AJ, Adams SE, Kingsman AJ, Layton GT. The effects of adjuvants on CTL induction by V3:Ty-virus-like particles (V3-VLPs) in mice. Vaccine. 1996; 14(10); 971-976. [PubMed: 8873390].