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Vaccine Detail
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Irradiated MBGV antigen |
| Vaccine Information |
- Vaccine Name: Irradiated MBGV antigen
- Target Pathogen: Marburg Virus
- Target Disease: Hemorrhagic fever
- Vaccine Ontology ID: VO_0004127
- Type: Inactivated or "killed" vaccine
- Antigen: Whole Marburg virus (MBGV) antigens (Hevey et al., 1997).
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| Host Response |
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Guinea pig Response
- Host Strain: Strain 13
- Vaccination Protocol: Animals were immunized with irradiated MBGV (strains Musoke and Ravn)(Hevey et al., 1997).
- Persistence: None noted.
- Immune Response: Not noted for irradiated MBGV specifically.
- Side Effects: None noted.
- Challenge Protocol: All animals challenged with strains Musoke and Ravn survived without regard to challenge virus (Hevey et al., 1997).
- Efficacy: Gradient-purified, irradiated virus was able to completely protect strain 13 guinea pigs from challenge with either MBGV (strain Musoke) or
indicated that the product immunoprecipitated from GP- MBGV (strain Ravn)(Hevey et al., 1997).
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| References |
Hevey et al., 1997: Hevey M, Negley D, Geisbert J, Jahrling P, Schmaljohn A. Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants. Virology. 1997 Dec 8; 239(1); 206-16. [PubMed: 9426460 ].
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