• Vaccine Name: DNA vaccine encoding ANDV glycoproteins
• Target Pathogen: Hantavirus
• Target Disease: Hantavirus Pulmonary Syndrome
• Vaccine Ontology ID: VO_0004119
• Type: DNA vaccine
• Antigen: Both the G1 and G2 glycoproteins are expressed (Custer et al., 2003).
• Hanta_G2 gene engineering:
  • Type: Recombinant protein preparation
  • Description: The Hantavirus G2 glycoprotein was expressed in the DNA vaccine (Custer et al., 2003).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000346
• Preparation: An expression plasmid, pWRG/AND-M, was constructed that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus (Custer et al., 2003).

Macaque Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV (a South American hantavirus) but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus (Custer et al., 2003).