• Vaccine Name: attenuated B. melitensis vaccine M5-90
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009616
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Sheep
• Antigen: BP26; OMP31
• Preparation: Live attenuated vaccine based on Brucella melitensis strain M5-90. (Wang et al, 2014a)
• Description: The attenuated Brucella melitensis vaccine M5-90 is currently used to vaccinate animals in China. Efficacy: Specific T-cell response induced by the M5-90 vaccine was relatively weak and did not sustain long enough, possibly due to rapid activation of T-regulatory cells following vaccination. Immune response: Low levels of antibodies to BP26 and OMP31 detected; specific IFN-γ responses quantified; identification of multiple T-cell epitopes reactive in vaccinated sheep; some epitope reactivity associated with MHC-I B allele. (Wang et al, 2014a)

Sheep Response

• Immune Response: Low levels of antibodies to BP26 and OMP31 detected; specific IFN-γ responses quantified; identification of multiple T-cell epitopes reactive in vaccinated sheep; some epitope reactivity associated with MHC-I B allele. (Wang et al, 2014a)
• Efficacy: Specific T-cell response induced by the M5-90 vaccine was relatively weak and did not sustain long enough, possibly due to rapid activation of T-regulatory cells following vaccination. (Wang et al, 2014a)
• Description: Evaluation of humoral and cellular immune responses to BP26 and OMP31 epitopes in vaccinated Chinese merino and Kazak sheep. (Wang et al, 2014a)