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Vaccine Detail

A19-ΔVirB12 vaccine strain

Vaccine Information

Vaccine Name: A19-ΔVirB12 vaccine strain
Target Pathogen: Brucella spp.
Target Disease: Brucellosis
Vaccine Ontology ID: VO_0009614
Type: Live attenuated vaccine
Status: Research
Host Species for Licensed Use: Cattle
Antigen: VirB12 gene deletion
Description: The A19-ΔVirB12 vaccine strain is a recently developed Brucella abortus vaccine strain carrying a deletion of the VirB12 gene, which complicates serological differentiation from wild-type infections. (Liang et al, 2026)

Host Response

References

Liang et al, 2026: Liang G, Li G, Liang T, Zhen Z, Teng C, Xiong J, Guangqiang J, Zheng M, Pan Y, Zhong S, Wu C, Li J, Huang W, Wei Z. Construction of an RAA-CRISPR detection platform for differentiation of Brucella abortus A19-∆VirB12 vaccine strain from wild-type strains. Journal of microbiological methods. 2026 Jun; 245; 107512. [PubMed: 41985719].