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Vaccine Detail
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H38ΔwbkF rough vaccine |
| Vaccine Information |
- Vaccine Name: H38ΔwbkF rough vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009610
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; Ovis aries (rams)
- Antigen: wbkF deletion; wadB deletion; wadC deletion (mutants studied)
- Preparation: Live attenuated rough mutant strain H38ΔwbkF administered by subcutaneous or conjunctival routes; conjunctival administration explored to reduce serological interference. (Lopez et al, 2026)
- Description: The vaccine is a rough mutant of Brucella melitensis strain H38 with deletion of wbkF gene, previously shown to protect rams against B. ovis infection without interfering in S-LPS-based serological tests. Efficacy: H38ΔwbkF vaccine protected rams against B. ovis infection similarly to B. melitensis Rev. 1 vaccine; core-defective mutants (wadB and wadC deletions) were over-attenuated and failed to protect mice; conjunctival administration preserved efficacy in rams. Immune response: H38ΔwbkF induced antibodies to rough LPS that interfered with B. ovis serological tests; conjunctival administration significantly reduced this serological interference compared to subcutaneous route. (Lopez et al, 2026)
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| Host Response |
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| References |
Lopez et al, 2026: Lopez N, Andrés-Barranco S, De Miguel MJ, Zúñiga-Ripa A, Elizalde-Bielsa A, Salvador-Bescós M, Iriarte M, Barberán M, Blasco JM, Moriyón I, Conde-Álvarez R, Muñoz PM. Conjunctival administration of H38ΔwbkF rough vaccine as an effective strategy to protect against Brucella ovis infection while minimizing serological interference. Veterinary research. 2026 Mar 08; 57(1); . [PubMed: 41794734].
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