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Vaccine Detail
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live attenuated Brucella ovis strain H38 delta wbkF delta wadC vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella ovis strain H38 delta wbkF delta wadC vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009609
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; Ovis aries (rams)
- Antigen: wbkF deletion; wadB deletion; wadC deletion
- Preparation: Live attenuated rough mutants with deletions in wbkF plus wadB or wadC genes; administered subcutaneously in mice. (Lopez et al, 2026)
- Description: Mutants of H38ΔwbkF vaccine with additional deletions in wadB or wadC genes, altering sugars of the rough LPS core tetrasaccharide branch, were constructed to minimize serological interference. Efficacy: These core-defective mutants were over-attenuated and failed to protect mice against infection. Immune response: Not reported beyond attenuation and protection failure. (Lopez et al, 2026)
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| Host Response |
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| References |
Lopez et al, 2026: Lopez N, Andrés-Barranco S, De Miguel MJ, Zúñiga-Ripa A, Elizalde-Bielsa A, Salvador-Bescós M, Iriarte M, Barberán M, Blasco JM, Moriyón I, Conde-Álvarez R, Muñoz PM. Conjunctival administration of H38ΔwbkF rough vaccine as an effective strategy to protect against Brucella ovis infection while minimizing serological interference. Veterinary research. 2026 Mar 08; 57(1); . [PubMed: 41794734].
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