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Vaccine Detail
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live attenuated Brucella melitensis strain Rev. 1 delta wzm vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis strain Rev. 1 delta wzm vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009555
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; Ovis aries (sheep)
- Antigen: wzm deletion (strain Rev1Δwzm)
- Preparation: Live attenuated Brucella melitensis strain Rev. 1 with wzm gene deletion; green fluorescent protein tagging was used to identify vaccinated sheep. (Mena-Bueno et al, 2024)
- Description: The vaccine candidate Rev1Δwzm was developed as a derivative of B. melitensis strain Rev. 1 with a wzm gene deletion, aiming to improve safety and efficacy compared to the conventional Rev. 1 vaccine, especially for use in both young and adult sheep. Efficacy: Rev1Δwzm protected rams against Brucella ovis infection 25 weeks after vaccination, demonstrating effective protection in the target host. Immune response: The vaccine induced a transient serological response in the Rose Bengal test in up to 50% of sheep, confirmed partially by complement fixation test, and elicited a stronger, more persistent anti-rough-LPS antibody response; green fluorescent protein tagging allowed differentiation of vaccinated animals despite serological interference. (Mena-Bueno et al, 2024)
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| Host Response |
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| References |
Mena-Bueno et al, 2024: Mena-Bueno S, Garrido V, Romero F, Zabalza-Baranguá A, Grilló MJ. Rev1Δwzm vaccine candidate is safe in young and adult sheep and protects against Brucella ovis infection in rams. Vaccine. 2024 Sep 17; 42(22); 125998. [PubMed: 38806353].
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