• Vaccine Name: live attenuated Brucella melitensis pgm gene deletion vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009534
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Goat
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: pgm gene deletion
• Preparation: Live attenuated strain with pgm gene deletion. (Czibener et al, 2023)
• Description: A novel highly attenuated vaccine strain constructed by clean deletion of the phosphoglucomutase (pgm) gene, which is involved in biosynthesis of polysaccharides including O-antigen and cyclic beta glucans. Efficacy: The vaccine confers excellent levels of protection against B. melitensis in mice and cross protection against B. abortus and B. suis. Immune response: Vaccination induces a robust memory cellular immune response but no antibody production against the O-antigen. (Czibener et al, 2023)

Mouse Response

• Immune Response: Vaccination induces a robust memory cellular immune response but no antibody production against the O-antigen. (Czibener et al, 2023)
• Efficacy: The vaccine confers excellent levels of protection against B. melitensis in mice and cross protection against B. abortus and B. suis. (Czibener et al, 2023)
• Description: Mouse model of infection used to evaluate protection against Brucella melitensis and cross protection against Brucella abortus and Brucella suis. (Czibener et al, 2023)