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Vaccine Detail
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live attenuated Brucella melitensis 16M delta wzm vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis 16M delta wzm vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009526
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: wzm deletion mutant
- Preparation: Live attenuated Brucella melitensis 16M strain with an in-frame deletion of the wzm gene, administered by subcutaneous or conjunctival routes. (Zabalza-Baranguá et al, 2023)
- Description: The study investigated the biological properties and safety of a Brucella melitensis 16MΔwzm in-frame deletion mutant as a vaccine candidate, focusing on its use in pregnant mice and sheep. Efficacy: In mice, 16MΔwzm prevented placental and fetal infections and protected against Brucella melitensis and Brucella ovis infections. Efficacy in the natural host (sheep) remains to be confirmed. Immune response: Vaccination induced transient Rose Bengal serological reactions, stronger and earlier in pregnant ewes; seroconversion in smooth and rough LPS tests was observed at parturition in some ewes, especially after subcutaneous vaccination. (Zabalza-Baranguá et al, 2023)
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| Host Response |
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| References |
Zabalza-Baranguá et al, 2023: Zabalza-Baranguá A, Poveda-Urkixo I, Mena-Bueno S, Ramírez GA, De Bolle X, Grilló MJ. Vaccine properties of Brucella melitensis 16MΔwzm and reactivation of placental infection in pregnant sheep. Vaccine. 2023 Feb 24; 41(9); 1554-1566. [PubMed: 36653223].
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