• Vaccine Name: live attenuated Brucella abortus strain 19 brucellaphage-treated vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009514
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Preparation: Brucella abortus strain 19 vaccine pulsed with lytic brucellaphage (phage pulsed vaccine preparation). (Mohan et al, 2020)
• Description: The live attenuated Brucella abortus strain 19 organisms commonly used as a vaccine were employed to deliver a broad acting lytic brucellaphage inside phagocytes in vivo to reach virulent Brucella hiding intracellularly. Efficacy: The phage pulsed vaccine induced sustained and significantly high titers of anti-Brucella antibodies compared with untreated animals and animals vaccinated with S19 vaccine alone. Immune response: Induction of specific and sustained high titers of anti-Brucella antibodies measured by multiple serological assays. (Mohan et al, 2020)

Cattle Response

• Immune Response: Induction of specific and sustained high titers of anti-Brucella antibodies measured by multiple serological assays. (Mohan et al, 2020)
• Efficacy: The phage pulsed vaccine induced sustained and significantly high titers of anti-Brucella antibodies compared with untreated animals and animals vaccinated with S19 vaccine alone. (Mohan et al, 2020)
• Description: Evaluation of specific antibody response in cattle by standard tube agglutination test, microagglutination test, indirect hemagglutination assay test, and enzyme-linked immunosorbent assay. (Mohan et al, 2020)