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Vaccine Detail
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live attenuated Brucella melitensis strain Rev. 1 wzm deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis strain Rev. 1 wzm deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009512
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; BeWo trophoblasts
- Antigen: wzm deletion
- Preparation: Live attenuated Brucella melitensis strain Rev. 1 with wzm gene deletion. (Mena-Bueno et al, 2022)
- Description: The study constructed wzm/wzt single- and double-deletion mutants using the attenuated Brucella melitensis strain Rev. 1 as the parental strain to investigate the biological implications of the Wzm/Wzt system and its potential as a vaccine. Efficacy: Rev1Δwzm mutant was highly attenuated yet immunogenic and effective as a vaccine against Brucella melitensis and Brucella ovis in mice; it showed low persistence but maintained efficacy. Immune response: Rev1Δwzm induced protective immunity without causing infection in mouse placentas and was safe in pregnant ewes, with minimal serological interference in sheep. (Mena-Bueno et al, 2022)
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| Host Response |
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| References |
Mena-Bueno et al, 2022: Mena-Bueno S, Poveda-Urkixo I, Irazoki O, Palacios L, Cava F, Zabalza-Baranguá A, Grilló MJ. Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties. Frontiers in microbiology. 2022; 13; 908495. [PubMed: 35875565].
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