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Vaccine Detail
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live attenuated Brucella ovis hdeA deletion mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella ovis hdeA deletion mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009506
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: hdeA deletion mutant
- Preparation: Live attenuated Brucella ovis PA strain with hdeA gene deletion; also combined with mucR deletion. (Tartilán-Choya et al, 2021)
- Description: The study also evaluated a hdeA deletion mutant and a double mucR and hdeA deletion mutant of Brucella ovis PA. Efficacy: Deletion of hdeA alone did not modify evaluated properties; however, the double mutant showed attenuation and persistence similar to mucR single mutant, supporting evaluation as attenuated vaccine candidates. (Tartilán-Choya et al, 2021)
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| Host Response |
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| References |
Tartilán-Choya et al, 2021: Tartilán-Choya B, Sidhu-Muñoz RS, Vizcaíno N. The Transcriptional Regulator MucR, but Not Its Controlled Acid-Activated Chaperone HdeA, Is Essential for Virulence and Modulates Surface Architecture and Properties in Brucella ovis PA. Frontiers in veterinary science. 2021; 8; 814752. [PubMed: 35174240].
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