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Vaccine Detail
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Brucella abortus strain 19 bacterial ghost vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus strain 19 bacterial ghost vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009502
- Type: Inactivated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: guinea pig
- Antigen: PhiX174 gene E lysed
- Preparation: The vaccine was prepared by sequential biological lysis and hydrogen peroxide treatment resulting in bacterial ghosts with typical morphology and genetic stability. (He et al, 2022)
- Description: The study developed a Brucella abortus A19 bacterial ghost vaccine using a double inactivation strategy combining biological lysis and hydrogen peroxide treatment to ensure complete inactivation and safety. Efficacy: Immunization with A19BG conferred a similar level of protection as the existing A19 vaccine against Brucella melitensis M28 in both guinea pigs and cattle. Immune response: Vaccinated guinea pigs showed antibody levels, interferon-γ, interleukin-4, and CD4+ T cell responses comparable to those induced by the existing A19 vaccine; no adverse reactions were observed. (He et al, 2022)
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| Host Response |
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| References |
He et al, 2022: He C, Yang J, Zhao H, Liu M, Wu D, Liu B, He S, Chen Z. Vaccination with a Brucella ghost developed through a double inactivation strategy provides protection in Guinea pigs and cattle. Microbial pathogenesis. 2022 Jan; 162; 105363. [PubMed: 34919994].
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