• Vaccine Name: live attenuated Brucella abortus Omp16 PEDV vector vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009492
• Type: Live attenuated vaccine + Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Pig
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: OMP16; PEDVS protein
• Preparation: Recombinant Lactobacillus casei expressing OMP16 and PEDVS proteins. (Li et al, 2021)
• Description: A novel recombinant Lactobacillus casei strain expressing PEDVS protein of PEDV and OMP16 protein of Brucella abortus strain was constructed as a candidate vaccine. Efficacy: The vaccine induced higher levels of humoral, cellular, and mucosal immunity compared to other recombinant protein controls. Immune response: Elevated serum IgG, neutralizing antibodies, IL-4, IL-10, INF-γ, and fecal IgA indicated strong humoral, cellular, and mucosal immune responses. (Li et al, 2021)

Mouse Response

• Immune Response: Elevated serum IgG, neutralizing antibodies, IL-4, IL-10, INF-γ, and fecal IgA indicated strong humoral, cellular, and mucosal immune responses. (Li et al, 2021)
• Efficacy: The vaccine induced higher levels of humoral, cellular, and mucosal immunity compared to other recombinant protein controls. (Li et al, 2021)
• Description: Immunization of mice followed by measurement of serum IgG, neutralizing antibody, IL-4, IL-10, INF-γ, and fecal IgA levels. (Li et al, 2021)