• Vaccine Name: Brucella abortus Omp19 recombinant vector vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009488
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Goat
• Host Species as Laboratory Animal Model: Capra hircus
• Antigen: Omp19
• Preparation: Attenuated Salmonella Typhimurium strain expressing Omp19 at 5 × 10‚Åπ CFU/mL in 1 mL. (Leya et al, 2021)
• Description: The vaccine uses an attenuated Salmonella Typhimurium strain as a vector to deliver the Brucella outer-membrane protein 19 (Omp19) antigen to goats. Efficacy: Vaccinated goats showed significantly higher serum IgG titers and interferon-γ production compared to vector control; reduced Brucella colonization in tissues; decreased Brucella antigen expression in spleen, kidney, and lymph nodes; amelioration of brucellosis-related histopathological lesions. Immune response: Induction of antigen-specific immune responses including increased serum IgG and interferon-γ production. (Leya et al, 2021)

Goat Response

• Immune Response: Induction of antigen-specific immune responses including increased serum IgG and interferon-γ production. (Leya et al, 2021)
• Challenge Protocol: Vaccination of goats followed by challenge with Brucella abortus at 6 weeks post-vaccination; measurement of serum IgG titers, interferon-γ production, Brucella colonization in tissues, real-time PCR for antigen expression, and histopathological analysis. (Leya et al, 2021)
• Efficacy: Vaccinated goats showed significantly higher serum IgG titers and interferon-γ production compared to vector control; reduced Brucella colonization in tissues; decreased Brucella antigen expression in spleen, kidney, and lymph nodes; amelioration of brucellosis-related histopathological lesions. (Leya et al, 2021)
• Description: Vaccination of goats followed by challenge with Brucella abortus at 6 weeks post-vaccination; measurement of serum IgG titers, interferon-γ production, Brucella colonization in tissues, real-time PCR for antigen expression, and histopathological analysis. (Leya et al, 2021)