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Vaccine Detail
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live attenuated Brucella abortus strain RB51 delta leuB recombinant FliC GnRH vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain RB51 delta leuB recombinant FliC GnRH vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009486
- Type: Live attenuated vaccine + Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Pig
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: leuB deletion; Salmonella typhimurium FliC; gonadotropin releasing hormone (GnRH)
- Preparation: Live attenuated Brucella abortus strain RB51 ΔleuB genetically engineered to express Salmonella FliC conjugated to GnRH DNA sequences. (Waldrop et al, 2021)
- Description: This vaccine candidate is a Brucella abortus strain RB51 with a leuB gene deletion expressing Salmonella typhimurium FliC protein conjugated to gonadotropin releasing hormone (GnRH) DNA sequences, designed as an immunocontraceptive and protective vaccine. Efficacy: Significant reduction in fertility characteristics observed in both male and female mice. (Waldrop et al, 2021)
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| Host Response |
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| References |
Waldrop et al, 2021: Waldrop SG, Smith GP, Boyle SM, Sriranganathan N. Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine. Heliyon. 2021 Feb; 7(2); e06149. [PubMed: 33644455].
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