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Vaccine Detail
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live attenuated Brucella ovis pyruvate phosphate dikinase deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella ovis pyruvate phosphate dikinase deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009470
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: pyruvate phosphate dikinase (PpdK) deletion mutant
- Preparation: Live attenuated mutant strains with deletion of the PpdK gene impairing growth and virulence. (Vizcaíno et al, 2020)
- Description: The study reports the generation of a pyruvate phosphate dikinase (PpdK) deletion mutant in Brucella ovis PA strains (both CO2-dependent and CO2-independent) as a potential vaccine candidate. Efficacy: The PpdK mutant showed impaired growth in vitro, inability to multiply in infected cells, and an unusual attenuation pattern in mice with initial higher spleen colonization followed by marked decrease, indicating attenuation and potential as a vaccine candidate. (Vizcaíno et al, 2020)
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| Host Response |
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| References |
Vizcaíno et al, 2020: Vizcaíno N, Pérez-Etayo L, Conde-Álvarez R, Iriarte M, Moriyón I, Zúñiga-Ripa A. Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO(2)-dependent and independent strains generates attenuation in the mouse model. Veterinary research. 2020 Aug 14; 51(1); 101. [PubMed: 32795361].
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