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Vaccine Detail
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Brucella canis RM6/66 ΔvjbR vaccine candidate |
| Vaccine Information |
- Vaccine Name: Brucella canis RM6/66 ΔvjbR vaccine candidate
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009458
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Dog
- Host Species as Laboratory Animal Model: Mus musculus; canine dendritic cells
- Antigen: vjbR deletion mutant
- Preparation: Live attenuated Brucella canis RM6/66 ΔvjbR strain administered at 10^9 CFU by intraperitoneal and subcutaneous routes; adjuvant addition or booster dose did not improve protection. (Stranahan et al, 2020)
- Description: The vaccine candidate is a live attenuated strain of Brucella canis RM6/66 with a deletion in the vjbR gene developed to protect against canine brucellosis, a disease with no current vaccine. Efficacy: Vaccinated mice showed significant protection against organ colonization and histopathologic lesions after challenge; booster or adjuvant did not enhance protection. Immune response: Vaccination induced a robust humoral immune response in mice and activated canine dendritic cells in vitro. (Stranahan et al, 2020)
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| Host Response |
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| References |
Stranahan et al, 2020: Stranahan LW, Chaki SP, Garcia-Gonzalez DG, Khalaf OH, Arenas-Gamboa AM. Evaluation of the Efficacy of the Brucella canis RM6/66 ΔvjbR Vaccine Candidate for Protection against B. canis Infection in Mice. mSphere. 2020 May 20; 5(3); . [PubMed: 32434839].
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