• Vaccine Name: inactivated methanol-killed Brucella abortus strain RB51 polyanhydride VPEAR vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009431
• Type: Inactivated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Antigen: RB51 antigen
• Preparation: Polyanhydride-based implantable delivery platform containing methanol-killed RB51 antigen. (Boggiatto et al, 2019)
• Description: The study reports fabrication of an implantable single dose polyanhydride-based, methanol-killed RB51 antigen containing delivery platform (VPEAR) for vaccination against bovine brucellosis. Efficacy: Initial vaccination with VPEAR did not induce measurable RB51-specific IFN-γ or IgG responses in peripheral blood; however, a subsequent booster with live RB51 induced an anamnestic response comparable in magnitude and kinetics to live RB51 vaccination alone; IgG titers were significantly higher in VPEAR vaccinated animals after booster. Immune response: VPEAR vaccination generated and sustained memory CD4+ IFN-γ-mediated T cell and humoral (IgG) responses against Brucella following booster vaccination, demonstrating the potential of killed antigen to induce protective immunity in the natural host. (Boggiatto et al, 2019)

Cattle Response

• Immune Response: VPEAR vaccination generated and sustained memory CD4+ IFN-γ-mediated T cell and humoral (IgG) responses against Brucella following booster vaccination, demonstrating the potential of killed antigen to induce protective immunity in the natural host. (Boggiatto et al, 2019)
• Efficacy: Initial vaccination with VPEAR did not induce measurable RB51-specific IFN-γ or IgG responses in peripheral blood; however, a subsequent booster with live RB51 induced an anamnestic response comparable in magnitude and kinetics to live RB51 vaccination alone; IgG titers were significantly higher in VPEAR vaccinated animals after booster. (Boggiatto et al, 2019)
• Description: Vaccination of cattle with VPEAR and comparison to live RB51 vaccination; measurement of RB51-specific IFN-γ, IgG responses, CD4+ IFN-γ-mediated responses, and circulating memory T cell subpopulations. (Boggiatto et al, 2019)