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Vaccine Detail
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live attenuated Brucella melitensis strain M5-90 vjbR deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis strain M5-90 vjbR deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009406
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; RAW 264.7 macrophages
- Antigen: vjbR deletion; VjbR antigen
- Preparation: Live attenuated Brucella melitensis M5-90 strain with vjbR gene deletion. (Li et al, 2018)
- Description: The M5-90ΔvjbR mutant was constructed from the Brucella melitensis M5-90 vaccine strain to overcome safety issues and enable differentiation of infected from vaccinated animals. Efficacy: M5-90ΔvjbR showed reduced survival in macrophages and mice, induced high protective immunity in mice, and stimulated specific IgG responses and cytokine production in both mice and sheep. Immune response: Induced anti-Brucella-specific IgG, stimulated gamma interferon (IFN-γ) and interleukin-4 (IL-4) expression in vaccinated mice and sheep; VjbR antigen enabled serological differentiation between infected and vaccinated animals. (Li et al, 2018)
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| Host Response |
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| References |
Li et al, 2018: Li Z, Wang S, Zhang H, Xi L, Zhang J, Zhang X, Zhou Q, Yi J, Li M, Zhang W, Zhang J. Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant. Microbial pathogenesis. 2018 Nov; 124; 250-257. [PubMed: 30149131].
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