• Vaccine Name: live attenuated Brucella melitensis conjunctival vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009405
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Sheep
• Host Species as Laboratory Animal Model: Ovis aries
• Description: The vaccine was administered as a single dose conjunctival vaccination against Brucella melitensis in sheep. Efficacy: Antibody titers increased significantly at the first month post-vaccination (p < 0.001) but began to decline by the second month; the vaccine was considered safe and effective for protecting sheep from brucellosis. Immune response: Significant increase in antibody titers at one month post-vaccination; biochemical parameters showed no significant changes in glucose, AST, ALT; total protein and ALP decreased significantly; LDH and total protein levels increased significantly after vaccination. (√áiftci et al, 2019)

Sheep Response

• Vaccination Protocol: Thirty sheep were vaccinated; blood samples were collected from the jugular vein over 4 months; antibody levels were measured by serum tube agglutination test; biochemical parameters including ALP, ALT, AST, LDH, glucose, total protein, and albumin were measured using a commercial autoanalyzer. (Çiftci et al, 2019)
• Immune Response: Significant increase in antibody titers at one month post-vaccination; biochemical parameters showed no significant changes in glucose, AST, ALT; total protein and ALP decreased significantly; LDH and total protein levels increased significantly after vaccination. (Çiftci et al, 2019)
• Efficacy: Antibody titers increased significantly at the first month post-vaccination (p < 0.001) but began to decline by the second month; the vaccine was considered safe and effective for protecting sheep from brucellosis. (Çiftci et al, 2019)
• Description: Thirty sheep were vaccinated; blood samples were collected from the jugular vein over 4 months; antibody levels were measured by serum tube agglutination test; biochemical parameters including ALP, ALT, AST, LDH, glucose, total protein, and albumin were measured using a commercial autoanalyzer. (Çiftci et al, 2019)