|
|
Vaccine Detail
|
Brucella canis BLSOmp31 subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella canis BLSOmp31 subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009376
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Dog
- Host Species as Laboratory Animal Model: Mus musculus; Canis lupus familiaris (Beagle dogs)
- Antigen: BLSOmp31
-
Adjuvant:
aluminum hydroxide gel
- Preparation: BLSOmp31 antigen adsorbed to aluminum hydroxide gel (BLSOmp31-AH). (Clausse et al, 2017)
- Description: Polymeric antigen BLSOmp31 is an immunogenic vaccine candidate that confers protection against Brucella canis in mice. This study evaluated the immunogenicity and safety of BLSOmp31 adsorbed to aluminum hydroxide gel in Beagle dogs. Efficacy: The vaccine elicited specific antibodies 3 weeks after the first immunization; annual booster induced comparable antibody responses. Antibodies showed high complement-dependent bactericidal activity against B. canis and enhanced bacterial uptake and destruction by neutrophils. Specific IgG was detected in preputial secretions of most immunized dogs. Humoral response did not interfere with routine agglutination tests. Immune response: The antibody profile corresponded to a marked Th2 response with predominance of IgG1 over IgG2. Cellular immune response was not detected in vitro or in vivo. (Clausse et al, 2017)
|
| Host Response |
|
|
| References |
Clausse et al, 2017: Clausse M, Díaz AG, Pardo RP, Zylberman V, Goldbaum FA, Estein SM. Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs. Veterinary immunology and immunopathology. 2017 Feb; 184; 36-41. [PubMed: 28166930].
|
|
