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Vaccine Detail
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live attenuated Brucella abortus strain IVK15 delta cydC vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain IVK15 delta cydC vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009360
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus; RAW264.7 cells
- Antigen: cydC gene deletion
- Preparation: Live attenuated mutant strain IVK15ΔcydC. (Truong et al, 2016a)
- Description: Constructed unmarked mutant by deleting cydC gene encoding ATP-binding cassette transporter protein from virulent Brucella abortus isolate IVK15 from Korean cow. Efficacy: Provided better protection against challenge with virulent B. abortus strain 2308 than commercial B. abortus strain RB51 vaccine in mice. Immune response: Elicited anti-Brucella specific IgG and IgG subclass responses; enhanced interferon-gamma secretion. (Truong et al, 2016a)
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| Host Response |
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Mouse Response
- Host cell type: RAW264.7
- Immune Response: Elicited anti-Brucella specific IgG and IgG subclass responses; enhanced interferon-gamma secretion. (Truong et al, 2016a)
- Efficacy: Provided better protection against challenge with virulent B. abortus strain 2308 than commercial B. abortus strain RB51 vaccine in mice. (Truong et al, 2016a)
- Description: Growth defect tested in RAW264.7 cells; attenuation and protective efficacy tested in BALB/c mice; immune responses measured by anti-Brucella IgG and IgG subclass, and interferon-gamma secretion. (Truong et al, 2016a)
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| References |
Truong et al, 2016a: Truong QL, Cho Y, Park S, Park BK, Hahn TW. Brucella abortus mutants lacking ATP-binding cassette transporter proteins are highly attenuated in virulence and confer protective immunity against virulent B. abortus challenge in BALB/c mice. Microbial pathogenesis. 2016 Jun; 95; 175-185. [PubMed: 27057678].
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