• Vaccine Name: live attenuated Brucella abortus L7/L12 Omp16 influenza viral vector vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009334
• Type: Live attenuated vaccine + Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Antigen: L7/L12; Omp16
• Adjuvant: Montanide Gel01
• Preparation: Influenza viral vector expressing Brucella abortus L7/L12 or Omp16 proteins formulated with Montanide Gel01 adjuvant. (Tabynov et al, 2015)
• Description: A novel influenza viral vector Brucella abortus vaccine expressing ribosomal proteins L7/L12 or Omp16 was created to provide cross-protection against Brucella melitensis in cattle. Efficacy: Provided 100% protection against abortion in vaccinated pregnant heifers and 90-100% cross-protection of heifers and their calves or fetuses after challenge with B. melitensis 16M; protection comparable to commercial B. abortus strain 19 vaccine; significant reduction in infection and colonization indices in tissues (P=0.02 to P<0.0001). (Tabynov et al, 2015)

Cattle Response

• Challenge Protocol: Vaccination of pregnant heifers followed by challenge with Brucella melitensis 16M; comparison with commercial Brucella abortus strain 19 vaccine and negative control (PBS+Montanide Gel01). (Tabynov et al, 2015)
• Efficacy: Provided 100% protection against abortion in vaccinated pregnant heifers and 90-100% cross-protection of heifers and their calves or fetuses after challenge with B. melitensis 16M; protection comparable to commercial B. abortus strain 19 vaccine; significant reduction in infection and colonization indices in tissues (P=0.02 to P<0.0001). (Tabynov et al, 2015)
• Description: Vaccination of pregnant heifers followed by challenge with Brucella melitensis 16M; comparison with commercial Brucella abortus strain 19 vaccine and negative control (PBS+Montanide Gel01). (Tabynov et al, 2015)