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Vaccine Detail
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live attenuated Brucella ovis wadB mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella ovis wadB mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009304
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: wadB
- Preparation: Live attenuated wadB mutant strain of Brucella ovis. (Soler-Lloréns et al, 2014)
- Description: The wadB mutant of Brucella ovis was generated by mutating the wadB gene, which encodes an LPS core glycosyltransferase, resulting in defects in LPS structure and outer membrane topology. Efficacy: The wadB mutant was attenuated in mice and protected them against B. ovis challenge. (Soler-Lloréns et al, 2014)
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| Host Response |
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Mouse Response
- Challenge Protocol: Attenuation and protective efficacy were tested in mice challenged with Brucella ovis. (Soler-Lloréns et al, 2014)
- Efficacy: The wadB mutant was attenuated in mice and protected them against B. ovis challenge. (Soler-Lloréns et al, 2014)
- Description: Attenuation and protective efficacy were tested in mice challenged with Brucella ovis. (Soler-Lloréns et al, 2014)
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| References |
Soler-Lloréns et al, 2014: Soler-Lloréns P, Gil-Ramírez Y, Zabalza-Baranguá A, Iriarte M, Conde-Álvarez R, Zúñiga-Ripa A, San Román B, Zygmunt MS, Vizcaíno N, Cloeckaert A, Grilló MJ, Moriyón I, López-Goñi I. Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice. Veterinary research. 2014 Jul 17; 45(1); 72. [PubMed: 25029920].
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