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Vaccine Detail
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live attenuated Brucella abortus strain 19 wzt gene deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain 19 wzt gene deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009291
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Antigen: wzt gene deletion
- Description: Allelic exchange plasmids of wzt gene were constructed and partially knocked out in Brucella abortus S19 to evaluate effects on immunity induction. Efficacy: Immunity-eliciting ability was similar to wzm mutant but reduced compared with the S19 strain; wzt gene may be more important in immunity regulation. Immune response: Cytokine secretion and INF-γ induction were measured; wzt deletion mutant induced immunity but less than S19. (Wang et al, 2014)
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| Host Response |
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| References |
Wang et al, 2014: Wang XR, Yan GM, Zhang R, Lang XL, Yang YL, Li XY, Chen S, Qian J, Wang XL. Immunogenic response induced by wzm and wzt gene deletion mutants from Brucella abortus S19. Molecular medicine reports. 2014 Feb; 9(2); 653-8. [PubMed: 24247358].
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